Acute and Subchronic Toxicity Evaluations of the Halon Replacement Candidate Phosphorus Tribromide

Abstract

Phosphorus tribromide (PBr3) is being considered by the DOD as a possible replacement for Halon 1301. This study was designed to determine the effects following single, high-concentration exposures which could occur in accidents, as well as repeated, low-concentration exposures which could occur on flight lines or where maintenance commonly occurs. Application of 10 or 50 microliters neat PBr3 to intact skin of an anesthetized NZW rabbit caused edema and necrosis of the treated skin within 10 minutes of dosing. Microscopic examination confirmed necrosis of the skin and underlying areas, including the skeletal muscle of the subcutis.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADA329386

Entities

People

  • Carlyle D. Flemming
  • David H Ellis
  • Harry F. Leahy
  • Marcia L. Feldmann
  • Robin E. Wolfe

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Blood
  • Body Weight
  • Bromine Compounds
  • Chemical Synthesis
  • Chemistry
  • Epithelium
  • Fish
  • Granulocytes
  • Lymphatic System
  • Medical Personnel
  • Mucous Membrane
  • Nose
  • Respiration Disorders
  • Skeletal Muscle
  • Tissues
  • Toxicity

Readers

  • Fire Suppression Systems Design.
  • Toxicology/Environmental Toxicology
  • Trauma Surgery or Emergency Medicine.