The Effects of Chronic JP-8 Jet Fuel Exposure on Lung Function.
Abstract
The past three years of work for the Air Force Office of Scientific Research has resulted in the development of a congenic mouse model of JP-8 jet fuel exposure, the role of substance P in the JP-8 jet fuel-induced lung injury process, and development of extensive collaborations with Dr David Harris (University of Arizona), Drs Korngut1 and Siegel (University of Wisconsin), and Dr Frank Witzman (Indiana University). We demonstrated that congenic mice deficient in the aryl hydrocarbon hydroxylase and N-acetyl transferase enzymes have increased lung permeability and pathological lung injury resulting from exposure to JP-8 jet fuel compared to their C57BL/6 parent strain. Consequently, we can conclude that one or both of these enzymes plays a role in the metabolism of JP-8 fuel in the lungs. Finally, we have conducted field studies for JP-8 jet fuel exposure at the Montana Air National Guard Base in Great Falls, Montana in March of 1997 and at Davis Montana Air Force Base in Tucson, Arizona. The purpose of this semi-cold weather (30 degree) F-16A engine start and warm weather (102 degree) F-16A engine start were to determine real-life' JP-8 jet fuel exposures at the ground crew positions and determine average JP-8 jet fuel concentration and particle size. The data was then compared against similar data generated in our JP-8 jet fuel exposure model.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 14, 1997
- Accession Number
- ADA330006
Entities
People
- Mark L. Witten
Organizations
- University of Arizona