Developing Novel Conjugate HIV-1 Subunit Therapeutic Vaccines

Abstract

Highly pure, native preparations of recombinant gp120 have been obtained from the T-tropic HIV-l(LAI) and the macrophage-tropic HIV-l(JR-FL) isolates. Conjugates of these HIV-l gp120 preparations were prepared with tetanus toxoid (TT) and keyhole limpet hemocyanin (KHL) with the hypothesis that very immunogenic carrier proteins will increase the immunogenicity of gp 120.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1997
Accession Number
ADA330147

Entities

People

  • Luis D. Giavedoni

Organizations

  • Texas Biomedical Research Institute

Tags

DTIC Thesaurus Topics

  • Antigens
  • Biological Factors
  • Biomedical Research
  • Carrier Proteins
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Hiv Infections
  • Immunity
  • Immunization
  • Immunogenicity
  • Lymphocytes
  • Molecules
  • Proteins
  • Rodents
  • Vaccines

Fields of Study

  • Biology

Readers

  • Immunology

Technology Areas

  • Biotechnology
  • Space