A Genetic Approach to Mammalian Circadian Rhythms.

Abstract

We have developed a routine procedure for random mutagenesis in the mouse and have demonstrated the feasibility of rapidly screening for aberrant behavioral parameters. We believe that this classical genetic approach, as well as the screening of progeny of mutagenized mice for altered sequence and/or expression pattern prior to phenotypic analysis, will play an important role in the elucidation of the functional content of the mammalian genome.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1995
Accession Number
ADA330711

Entities

People

  • Maja Bucan

Organizations

  • University of Pennsylvania

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Anxiety Disorders
  • Biological Processes
  • Circadian Rhythms
  • Diseases And Disorders
  • Ear
  • Genes
  • Genetic Mapping
  • Genetic Phenomena
  • Genetic Structures
  • Genetics
  • Mathematics
  • Mutations
  • Neurodegeneration
  • Personality Disorders
  • Psychiatry
  • Sequences
  • Statistical Analysis

Fields of Study

  • Biology

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Immunology
  • Molecular Genetics

Technology Areas

  • Biotechnology