Evaluation of Potential Antileishmanial Drugs in Animal Models.
Abstract
A total of 16 selected compounds which included some natural products as well as drugs known to be efficacious against other diseases were studied at various dosage levels and via various routes of administration in hamsters for antileishmanial efficacy against visceral leishmaniasis (Leishmania Leishmania donovani) and three of the same compounds were studied for activity against cutaneous leishmaniasis (Leishmania Vianni panamensis). None of these were efficacious against either leishmania but several were toxic to the host. Leishmanial cutaneous lesion development in golden hamsters is very helpful, along with other procedures, for the confirmation of the presence of Leishmania in cultures obtained by WRAIR from patients with suspected infections with these parasites. The infection of golden hamsters with several species of Leishmania of human origin (identified in other laboratories by biochemical typing as Leishmania Viannia panamensis, Leishmania Leishmania mexicana, and Leishmania Viannia braziliensis) resulted in clinical disease similar to that seen in human beings. Thus a laboratory animal model is now in place for the performance of drug sensitivity studies on these new isolates of Leishmania, some of which apparently had various degrees of susceptibility to current therapeutic drugs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1997
- Accession Number
- ADA331265
Entities
People
- William L. Hanson
Organizations
- University of Georgia Research Foundation