Xenograft Studies of Fatty Acid Synthesis Inhibition as Novel Therapy for Breast Cancer

Abstract

Fatty acid synthesis inhibitors were studied as a means to treat breast cancer in vivo. A nude mouse model of MDA-435 was validated and the fatty acid synthesis inhibitor, C-75, was shown to substantially inhibit the growth of MDA- 435 in a local intraperitoneal treatment model. Studies were carried out addressing the mechanism of C-75 which, while not yet conclusive, have shown a degree of fatty acid synthase inhibition. Additional candidate compounds for in vivo analysis have been identified.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1997
Accession Number
ADA332321

Entities

People

  • Gay R. Pasternack

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Acetic Acid
  • Acids
  • Animals
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Chemistry
  • Fatty Acids
  • Inhibition
  • Inhibitors
  • Laboratory Animals
  • Lipids
  • Materials
  • Neoplasms
  • Recombinant Dna
  • Xenografts

Readers

  • Microbial Pathology
  • Oncology (Cancer Research).