Evaluating Gene Therapy Approaches for the Prevention of Breast Cancer
Abstract
In order to determine the feasibility of using gene therapy for breast cancer prevention in the rat, lacZ recombinant adenoviral and retroviral vectors were infused into the mammary glands of rats in situ. Staining of whole glands with X-gal revealed the location of infected cells. Adenovirus infected the end buds with high efficiency but failed to infect the primary/secondary ductal cells. Expression of lacZ from the adenoviral vector was transient, with no expression by day 8 post-infusion.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1997
- Accession Number
- ADA332329
Entities
People
- Michael N. Gould
- Philip Watson
Organizations
- University of Wisconsin–Madison