Role of Bone Sialoproteins in Osseous Metastasis of Breast Cancer

Abstract

The ability of certain human breast cancer cells (HBC) to metastasize to bone may be related to cellular expression of the small acidic sialoproteins osteopontin (OPN) and bone sialoprotein (BSP). Expression of these proteins may promote primary tumor cell invasion, and/or the development of bone metastases. The purpose of this study is to compare BSP and OPN expression in HBC to bone metastatic potential and to examine potential breast cancer cell responses to BSP.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1997
Accession Number
ADA332341

Entities

People

  • Victoria Sung

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Adhesives
  • Albumins
  • Amino Acids
  • Biological Sciences
  • Bone And Bones
  • Bone Diseases
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Ribonucleic Acids

Readers

  • Oncology (Cancer Research).