Mechanisms Underlying the Very High Susceptibility of the Immature Mammary Gland to Carcinogenic Initiation

Abstract

The overall goal of this proposal is to explore the hypothesis that the diminished ability of mammary cells from immature rats to recover from cytotoxic radiation damage may extend to an increased susceptibility to mammary carcinogenesis. If so, such a mechanism may also underlie the observation that the immature breast of prepubertal human females is the developmental stage most highly susceptible to breast cancer initiation. It is further hypothesized that this low capacity of cells in prepubertal glands to recover from radiation damage is the result of a maturation stage-related lack of TGFalpha production. TGF alpha apocrine/paracrine interaction and its resultant intracellular signaling may be needed to provide the required gene expression for cellular recovery from radiation damage.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1997
Accession Number
ADA332451

Entities

People

  • Michael N. Gould

Organizations

  • University of Wisconsin–Madison

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Diseases And Disorders
  • Epidemiology
  • Epithelial Cells
  • Gene Expression
  • Growth Factors
  • Ionizing Radiation
  • Mammary Glands
  • Medical Personnel
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Radiation
  • Tissues
  • Two Dimensional

Readers

  • Molecular Biology and Genetics