Transgenic Repository for Breast Cancer Research.

Abstract

The overall goal of this project is to develop and maintain a resource of mouse models for breast cancer research. In the 03 year 12 induced mutant strains have been identified and accepted for importation into The Jackson Laboratory (TJL) Induced Mutant Resource (IMR) repository for breast cancer research models. The importation process frees mice of infectious pathogens. Embryos or gametes are cryopreserved. Correct nomenclature is assigned, efficient breeding strategies are developed, and genotyping protocols are modified for optimal efficiency and accuracy. Strain availability is announced in several media, including a page on the IMR's World Wide Web site, accessed through TJL's WWW home page. A principal aim of this project is to transfer relevant mutations to a defined genetic background. Nine mutations are being transferred, including 7 to the FVB/NJ inbred background. Reports by others and our own observations suggest that tumor characteristics may be altered as a consequence of background strain modifiers. Congenic strains require characterization of tumor onset and type.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1997
Accession Number
ADA332636

Entities

People

  • Mauriel T. Davisson

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Breeding
  • Cancer
  • Carcinoma
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Epithelial Cells
  • Genetics
  • Growth Factors
  • Mammary Glands
  • Medical Personnel
  • Nomenclature
  • Polymerase Chain Reaction
  • World Wide Web

Fields of Study

  • Biology

Readers

  • Library and Information Science
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology