Effects of Serotonergic Compounds on Stress-Induced Behavior in Rats.

Abstract

Because our earlier experiments with fenfluramine and serotonin antagonists did not provide encouraging results, we decided to study effects of endotoxin (lipopolysaccharide, LPS) and interleukin- 1, (IL-1) which are known to reduce food intake, and which we have shown also alter cerebral serotonergic and noradrenergic metabolism. Thus it is possible that there is a relationship between the activation of these cerebral neurotransmitter systems and the hypophagia. Specifically, it can be hypothesized that LPS- and IL-1-induced hypophagia are related to the increased noradrenergic and serotonergic activity. This hypothesis has been tested using a variety of neurotransmitter receptor antagonists for their ability to antagonize LPS- or IL-1-induced hypophagia in mice. Several behavioral experiments were completed.

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Document Details

Document Type
Technical Report
Publication Date
Aug 31, 1997
Accession Number
ADA332827

Entities

People

  • Adrian J. Dunn
  • Artur H. Swiergiel

Organizations

  • LSU Health Sciences Center New Orleans

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amines
  • Biochemistry
  • Body Weight
  • Brain
  • Chemical Compounds
  • Chemistry
  • Classification
  • Cytokines
  • Digestive System Processes
  • Endotoxins
  • Histamine
  • Human Behavior
  • Infection
  • Neurosciences
  • Neurotransmitters
  • Peptide Growth Factors
  • Serotonin

Fields of Study

  • Medicine
  • Psychology

Readers

  • Allergy and Immunology.
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Toxicology/Environmental Toxicology