The Identification of Estrogen Responsive Genes in the Hypothalamic-Pituitary Axis
Abstract
Estrogen mediates its biological responses through a specific interaction with the estrogen receptor (ER), an intracellular transcription factor which can bind specific DNA sequences and regulate gene expression. This process, however, is highly dependent on the cell and promoter context of the DNA-bound receptor, and our laboratory has demonstrated that the nature of the ligand also plays an important role. The identification of novel tissue-specific genes can therefore aid in the development of selective ligands for ER. Our laboratory is interested in defining estrogen-responsive genes in the hypothalamic-pituitary axis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1997
- Accession Number
- ADA332867
Entities
People
- Caroline E. Connor
- Donald P. Mcdonald
Organizations
- Duke University Hospital