Expression of Novel Steroid/Receptors in Mammary Development: Peroxisome Proliferator Activated Receptors.

Abstract

This research will determine the expression pattern of a novel class of nuclear hormone receptors, the peroxisome proliferator activated receptors (PPARs), during mammary gland development in rodent models. The long-term goal of these studies is to determine if PPARs represent a potential target for the treatment of mammary tumors. The studies in this IDEA grant are limited to murine and rat models. They combine immunohistochemical and molecular biological approaches to examine the expression profile the different PPAR genes in mammary tissues from virgin, pregnant, and lactating mice and in rat mammary tumors induced by 7,12-dimethylbenzanthracene (DMBA).

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1997
Accession Number
ADA332868

Entities

People

  • Jeffrey M. Gimble

Organizations

  • Oklahoma Medical Research Foundation

Tags

DTIC Thesaurus Topics

  • Adipose Tissue
  • Animals
  • Antibodies
  • Biomedical Research
  • Breast Cancer
  • Cells
  • Chemistry
  • Chemotherapeutic Agents
  • Cytoplasmic Granules
  • Epithelial Cells
  • Laboratory Animals
  • Mammary Glands
  • Materials
  • Neoplasms
  • Proteins
  • Recombinant Dna
  • Stromal Cells

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Prostate Cancer Biology.