Identification of Two Candidate Tumor Suppressor Genes on Chromosome 17p13.3: Assessment of Their Roles in Breast and Ovarian Carcinogenesis
Abstract
Breast cancer is one of the most common malignancies affecting women in the US. Despite the magnitude of this disease little is known about the molecular events that occur during its development. We have identified a region of less than 30 kbp, on chromosome l7pl3.3 by allelic loss mapping, which is altered in >50% of the breast tumors analyzed. Using positional cloning techniques we have identified a gene, OVCA2, within this region, which we believe may be a tumor suppressor gene.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1997
- Accession Number
- ADA332875
Entities
People
- Andrew K. Godwin
Organizations
- Fox Chase Cancer Center