The Relationship of Bacterial Contamination and Interleukin-6 in Amniotic Fluid in Preterm Labor and Delivery.

Abstract

Amniotic fluid (AF) was collected from 54 women with preterm labor at the Tripler and Madigan Army Medical Centers from 19 Dec 94-30 Sep 95. The AF was evaluated by standard culturing methods for aerobic and anaerobic bacteria as well as Mycoplasma. At the time of amniocentesis, 5 mL of AF was aspirated and frozen for detection of bacteria and Mycoplasma by the polymerase chain reaction (PCR) and for interleukin-6 studies. Approximately 55% of the patient AF samples were positive for bacteria by the PCR, whereas the culture data detected bacteria in approximately 9% of the samples. Interleukin-6 was found to be elevated above 600 pg/mL in nine samples. Patient whose amniotic fluid IL-6 levels exceeded 600 pg/mL delivered preterm. The sensitivity of the PCR assay and the prognostic value of IL-6 as markers of preterm labor and delivery are discussed.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1996
Accession Number
ADA332980

Entities

People

  • Rodger K. Martin

Organizations

  • Madigan Army Medical Center

Tags

DTIC Thesaurus Topics

  • Amniocentesis
  • Amniotic Fluid
  • Anaerobic Bacteria
  • Anti-Bacterial Agents
  • Bacteria
  • Bacterial Infections
  • Chain Reactions
  • Chemical Reactions
  • Chemistry
  • Data Analysis
  • Escherichia Coli
  • Infection
  • Materials
  • Membranes
  • Polymerase Chain Reaction
  • Pregnancy Complications
  • Standards

Fields of Study

  • Medicine

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