Receptors, Afferent Signaling and Central Integration in Compensated and Uncompensated Hemorrhagic Shock.

Abstract

To examine the mechanisms by which melanopeptides and hypertonic saline activate pressor mechanisms during hemorrhagic shock. Approach: Hemorrhagic shock is induced in rats by the controlled withdrawal of specific blood volumes, graded by body weight. Mean arterial pressure (MAP) and heart rate (HR) serve as indices of cardiovascular flinction, and ultimately as indicators of hemorrhage-induced shock. In this model of hemorrhagic shock, the melanopeptide, y-MSH, is administered peripherally or centrally, post-hemorrhage, to determine the therapeutic potential of the compound in treating hemorrhagic shock. The ability of y-MSH and hypertonic saline to increase survivability under the condition of hemorrhagic shock is being evaluated.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1997
Accession Number
ADA333265

Entities

People

  • Alan K. Johnson

Organizations

  • University of Iowa

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Arteries
  • Autonomic Nervous System
  • Blood
  • Blood Volume
  • Body Weight
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Catheters
  • Central Nervous System
  • Frequency Response
  • Heart Rate
  • Hemorrhage
  • Hemorrhagic Shock
  • Hypertonic
  • Hypotension
  • Infusions
  • Nervous System

Fields of Study

  • Medicine
  • Psychology

Readers

  • Cardiovascular Physiology