Custom Tailoring Therapy for Breast Cancer Using erbB-2

Abstract

In order to examine the role of erbB-2 as a therapeutic response variable in breast cancer, 937 cases from NSABP B-l4 and 207 cases from NSABP B-11 were examined using immunohistochemical assay. Both studies failed to demonstrate the value of erbB-2 in predicting response to specific treatment regimens used in the studies (tamoxifen or adriamycin). In order to clone additional therapeutic response variables that may predict response to tamoxifen, we have used gene trap approach. A novel estrogen suppressed gene was partially cloned. in addition, we were able to confirm estrogen regulation of bcl-2 gene, which could be a potential predictor of tamoxifen response.

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Document Details

Document Type
Technical Report
Publication Date
Jun 05, 1995
Accession Number
ADA333279

Entities

People

  • Soonmyoung Paik

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Apoptosis
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Diseases And Disorders
  • Estrogens
  • Laboratory Animals
  • Mammary Glands
  • Materials
  • Molecules
  • Multivariate Analysis
  • Neoplasms
  • Polymerase Chain Reaction
  • Regulations
  • Statistical Analysis
  • Tumor Cell Line

Readers

  • Breast cancer cell signaling and growth regulation.
  • Computational Modeling and Simulation
  • Oncology (Cancer Research).