Suppression of Lymphocyte Signal Transduction by Oxygen Intermediates

Abstract

Effects of different types of oxidative stress (OS) on cellular anti-oxidant mechanisms were compared. Human blood lymphocytes were subjected to: a. Acute exposure to H2O2; b. Chronic exposure to H2O2; c. Ionizing radiation. Enhanced catalase activity was detected in human peripheral blood T lymphocytes exposed to oxidative stress. Glutathione peroxidase activity and reduced glutathione, vitamin C and vitamin E levels, were not modulated by oxidative stress. Only exposure to hydrogen peroxide at 20 micrometer did not enhance catalase activity in T lymphocytes.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1997
Accession Number
ADA333384

Entities

People

  • Eliezer Flescher

Organizations

  • NYU Langone Health

Tags

DTIC Thesaurus Topics

  • Blood
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemical Synthesis
  • Chemistry
  • Culture Media
  • Health Services
  • Lymphocytes
  • Organic Chemistry
  • Proteins
  • Vitamin C

Fields of Study

  • Biology

Readers

  • Immunology and Pathology
  • Nuclear and Radiation Engineering.