The Roles of Nitric Oxide, cGMO, and cGMP-Dependent Protein Kinase in Generation and Modulation of Circadian Rhythms by the Suprachiasmatic Nucleus

Abstract

Research in this thesis addresses these two functions of the mammalian circadian pacemaker at a neurochemical level, examining the regulation of guanosine cyclic 3',5'- monophosphate (cGMP) and cGMP-dependent protein kinase (PKG) as components of the circadian pacemaker, and also investigating the roles of nitric oxide, cGMP, and PKG in transmitting environmental light cycle information to the pacemaker, possibly through regulation of the transcriptional factor, cAMP-response element binding protein (CREB).

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1995
Accession Number
ADA334527

Entities

People

  • Edward T. Weber

Organizations

  • Air Force Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Brain
  • Chemical Synthesis
  • Chemistry
  • Circadian Rhythms
  • Enzyme Inhibitors
  • Medical Personnel
  • Neurology
  • Neurosciences
  • Organic Chemistry
  • Polymer Chemistry
  • Polymeric Films
  • Proteins

Fields of Study

  • Biology

Readers

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  • Neuroscience