Interaction of Light and Clock Regulation in Neurospora
Abstract
Interest is focused on understanding the molecular mechanisms involved in how eukaryotic cells and organisms keep time on a daily basis and how visible light entrains the clock mechanism at the molecular level (Seminars in the Neurosciences, 7: 3-13, 1995). In the model organism, Neurospora crassa, ambient light has been shown to act either independently of, or coordinately through the circadian pacemaker. Significant advances in our understanding of how light effects a single component of the clock and thereby results in entrainment of clock phase has been made by examinaion of light effects on the frequency locus transcript, a known component of the I clock (Cell 81, 1003 - 1012, 1995). Analysis of clock-output genes find them involved in a diverse set of cell functions, photo-inducibility to be clock independent. Promoter resection analysis shows sequences necessary and sufficient for clock-independent light regulation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1997
- Accession Number
- ADA334721
Entities
People
- Jennifer J. Loros
Organizations
- Geisel School of Medicine