Relationships of Blood and Brain Halocarbon Solvent Concentrations to Neurobehavioral Toxicity

Abstract

Time-courses of blood and brain concentrations and neurobehavioral toxicity were determined for two halocarbon solvents in two rodent species. Based on these data, quantitative relationships, or the lack thereof, have been reported between the degree of neurobehavioral toxicity and internal measures of dose. In the case of orally- administered perchloroethylene (PCE), relationships between blood and brain concentrations and operant performance were not discernable, due in part to an acute adaptation of rats to PCE's response suppressing effect. For inhaled 1,1,1- trichloroethane (TRI), blood and brain concentrations were strongly correlated with the rate of operant responding in rats.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1995
Accession Number
ADA334733

Entities

People

  • David A. Warren

Organizations

  • Air Force Research Laboratory

Tags

DTIC Thesaurus Topics

  • Analysis Of Variance
  • Blood
  • Central Nervous System Depressants
  • Chemistry
  • Databases
  • Drug Abuse
  • Drug Addiction
  • Environmental Protection
  • Health Services
  • Human Behavior
  • Hypnotics And Sedatives
  • Information Processing
  • Information Science
  • Laboratory Animals
  • Measurement
  • Pharmacology
  • Regression Analysis

Fields of Study

  • Biology
  • Psychology

Readers

  • Theoretical Analysis.
  • Toxicology/Environmental Toxicology