Breast Tumorigenesis: Interaction of Two Signaling Pathways- -TGF- -beta versus Estrogen Receptor.

Abstract

The overall goal of this research project is to explore the roles of TGF-Beta and components of its signaling pathways in the initiation, progression and metastasis of breast adenocarcinomas through an investigation of the disregulation of TGF-Beta signal transduction. Last year, we identified and isolated three cDNAs encoding members of the Smad family and studied the TGF-Beta induced phosphorylation of these molecules in a normal mammary epithelial cell line. Subsequently, we have focused on the functional role of Smad3 and Smad4 as tumor suppressors in mediating the TGF-Beta signal in transactivating downstream target genes. We have extended our analysis of the biological activity of the Smad proteins in TGF-Beta signaling by studying the nuclear activity of Smad2, Smad3 and Smad4. Results from further analysis in these directions will not only significantly contribute to an understanding of the molecular events leading to breast carcinogenesis, but also aid in the development of new therapeutics for breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1997
Accession Number
ADA334783

Entities

People

  • Jonathan Yingling
  • Xiao-Fan Wang

Organizations

  • Duke University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical And Dental Materials
  • Cancer
  • Carrier Proteins
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chromosomes
  • Essential Amino Acids
  • Genetics
  • Growth Factors
  • Hormones
  • Materials
  • Peptide Growth Factors
  • Peptides
  • Transcription Factors

Fields of Study

  • Medicine

Readers

  • Molecular Biology and Genetics