Function of Cell Cycle Control Proteins in Breast Cancer.

Abstract

Loss of the retinoblastoma tumor suppressor protein (pRb) can contribute to breast tumor formation. However, many breast tumors retain expression of normal pRb, indicating that other genetic events may interfere with the function of this growth regulatory protein. Overexpression of cyclin Dl is such an event, since high levels of this protein may lead to constitutive inactivation of pRb through phosphorylation.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADA334893

Entities

People

  • Phillip W. Hinds

Organizations

  • Harvard Medical School

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Apoptosis
  • Breast Cancer
  • Calcium Compounds
  • Carrier Proteins
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Cultured Cells
  • Materials
  • Mutant Proteins
  • Neoplasms
  • Phosphorylation
  • Programmed Cell Death
  • Proteins
  • Transcription Factors

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology