Development of PEA3 as a Potential Gene Therapy Agent for Breast Cancer

Abstract

13. ABSTRACT (Maximum 200 The HER-2/neu gene is frequently amplified and /or its protein product, p185, is frequently overexpressed in a number of human cancers. Overexpression of p185 correlates with poor prognosis and low survival rates in breast and ovarian cancer patients. Downregulation of HER-2/neu gene is a way to reverse the transformation phenotype induced by HER-2/neu. In this project, the effects of PEA3, a member of ets oncogene family of transcriptional regulatory factors, on HER-2/neu expression were investigated to learn whether PEA3 plays a role in HER-2/neu induced transformation and could be developed to a gene therapeutic agent. This progress report includes our recent data which demonstrating that, PEA3 is indeed a trans-repressor of HER-2/neu promoter in HER-2/neu overexpressing human cancer cells.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADA334912

Entities

People

  • Xing Xiangming

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Army
  • Biology
  • Breast Cancer
  • Cancer
  • Carcinoma
  • Cell Line
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Fibroblasts
  • Gene Expression
  • Gene Therapy
  • Lung Cancer
  • Medical Personnel
  • Neoplasms
  • Ovarian Cancer
  • Therapy

Fields of Study

  • Biology

Readers

  • Environmental Impact Assessment (EIA) of Proposed Air Force Base Actions.
  • Molecular Biology and Genetics
  • Oncology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech