A Novel Tyrosine Kinase Expressed in Breast Tumors
Abstract
Tyrosine kinases mediate cellular responses to environmental conditions, and they are involved in regulation of proliferation and cell differentiation in a variety of systems. Overexpression or mutation of tyrosine kinases has been shown to result in cellular transformation, and this has been seen in breast tumors. Our laboratory identified a novel mouse epithelial cell specific intracellular tyrosine kinase, which we named Sik, for Src-related intestinal kinase. We isolated the human homologue of Sik and determined that it is identical to a novel tyrosine kinase termed Brk (Breast tumor kinase). Brk was
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1997
- Accession Number
- ADA334915
Entities
People
- Angela Tyner
Organizations
- University of Illinois at Chicago