TGFa-myc Interactions in Mammary Tumorigenesis.

Abstract

This grant continues to study the nature of the synergistic interaction of the growth factor TGF alpha and the nuclear protooncogene product c-myc for bitransgenic mouse mammary tumorigenesis. We found evidence of a mu!tifactoral interaction of the two genes, involving cooperative stimulation of proliferation, anchorage independent colony formation, and suppression of cell death (apoptosis). In addition, we observed that the TGF alpha-related growth factor amphiregulin was likely to have tumor promoting effects similar to"TGF alpha in breast' cancer.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADA334931

Entities

People

  • Robert B. Dickson

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biological Factors
  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Epithelial Cells
  • Genetics
  • Growth Factors
  • Neoplasms
  • Oncology
  • Peptide Growth Factors
  • Peptides
  • Programmed Cell Death
  • Proteins
  • Salivary Glands

Fields of Study

  • Medicine

Readers

  • Molecular Biology and Genetics