Improved 5-Fluorouracil Chemotherapy in Breast Cancer Patients by Monitoring Dihydropyrimidine Dehydrogenase Activity

Abstract

Dihydropyrimidine Dehydrogenase (DPD) is the initial, rate-limiting enzyme in catabolism of 5- fluorouracil (5-FU), one of the most widely used chemotherapeutic agents in the treatment of breast cancer. The purpose of this project is to improve 5-FU-based chemotherapy by monitoring DPD.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADA335055

Entities

People

  • Zhihong Lu

Organizations

  • University of Alabama

Tags

DTIC Thesaurus Topics

  • Antineoplastic Agents
  • Blood
  • Catabolism
  • Chemistry
  • Chemotherapeutic Agents
  • Chemotherapy
  • Cirrhosis
  • Colon Cancer
  • Correlation Analysis
  • Diseases And Disorders
  • Health Services
  • Liquid Chromatography
  • Liver Diseases
  • Medical Personnel
  • Metabolism
  • Neoplasms
  • Statistical Analysis

Fields of Study

  • Chemistry

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Chemistry (specifically Chemical Fluorescence)
  • Oncology