Cell-Matrix Interactions in Breast Cancer Cells

Abstract

In the normal breast, epithelial cells adhere to the connective tissue via junctions called hemidesmosomes. Using in vitro models, we have shown that hemidesmosomes play an important role in determining correct tissue architecture in the developing breast. They do so by the coordinated function of a matrix component (laminin-5) and its integrin receptors. Laminin-5 appears to direct hemidesmosome assembly as well as breast epithelial duct morphogenesis. To do so this matrix element requires precise

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADA335059

Entities

People

  • Jonathon C. Jones

Organizations

  • Northwestern University

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Membrane Structures
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Intercellular Junctions
  • Medical Personnel
  • Skin Diseases

Readers

  • Molecular Biology and Genetics