Gene Therapy Mediated Breast Cancer Immunity
Abstract
We sought to optimize the conditions under which B7-mediated gene transfer could effect antitumor immunity. Transduction of murine mammary carcinoma cell lines and human breast cancer cell lines with adenoviruses expressing B7-1 led to high levels of B7 expression. The expression - of mB7-1 on melanoma cells but not mammary carcinoma cells results in reduced growth rate. Interestingly, adenovims-mediated expression of mB7-1 on mammary carcinoma cells did not result in a reduced tumor growth rate.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1997
- Accession Number
- ADA335064
Entities
People
- Heike Boxhorn
- Stephen Eck
Organizations
- University of Pennsylvania