The Role of Integrins in Breast Cancer Metastasis

Abstract

Our objective is to investigate the role of integrins in metastasis in human breast cancer. Integrins play an important role in cell adhesions and interactions with extracellular matrix proteins and the maintenance of normal differentiation. The scope of the study is to use variants of human breast cancer cell lines that differ in integrin expression to examine the relationship between integrin expression and metastasis to different organs. Variants of the human breast cancer cell line MDA-MB-435 with elevated expression expression of alpha v and alpha 6 integrins are highly metastatic to the lungs of nude mice. differences in expression of alternate

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADA335089

Entities

People

  • Janet Price

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Adhesion
  • Biomedical Research
  • Blood
  • Bone And Bones
  • Bone Marrow
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Diseases And Disorders
  • Materials
  • Neoplasms
  • Proteins
  • Surgery
  • Survival
  • Tissues
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics