Tuning Biphenyl Dioxygenase for Extended Substrate Specificity and Enhanced Activity

Abstract

At the time when public concern about PCBs contamination in the environment is increasing, there is also an increasing interest in the development of novel biodegradation processes that can rapidly and effectively remove PCB's. However, some of the PCB congeners are known to be very resistant to aerobic biodegradation, particularly in the initial attack by the biphenyl dioxygenases. We seek to broaden the substrate specificity of biphenyl dioxygenase from Pseudomonas sp.

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Document Details

Document Type
Technical Report
Publication Date
Sep 30, 1997
Accession Number
ADA335315

Entities

People

  • Wilfred Chen

Organizations

  • University of California, Riverside

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Amino Acids
  • Biodegradation
  • Biphenyl
  • Degradation
  • Environment
  • Genetic Phenomena
  • Genetic Structures
  • Information Operations
  • Military Research
  • Monitoring
  • Mutations
  • Pseudomonas Infections
  • Sequences
  • Substrate Specificity
  • Substrates
  • Universities

Readers

  • Analytical Chemistry
  • Groundwater Contamination Remediation.
  • Molecular and Cellular Biochemistry