The Role of Basic Fibroblast Growth Factor in Human Breast Cancer

Abstract

We have demonstrated that recombinant basic fibroblast growth factor (bFGF) inhibits proliferation and promotes programmed cell death in MCF-7 and a number of other breast cancer cells. These effects are opposite of the effects seen in fibroblasts. Since bFGF acts as a key angiogenesis factor in breast cancer and the bFGF content of breast cancer cells diminishes as they progress toward an ever more malignant phenotype, we investigated the effects of overexpressing bFGF in MCF-7 cells on the survival of these cells following treatment with two chemotherapeutic agents, etoposide and 5-fluorouracil. We contrasted these finding with data obtained in NIH 3T3 fibroblasts also transduced with bFGF.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADA335806

Entities

People

  • Robert Wieder

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chemotherapeutic Agents
  • Fibroblasts
  • Growth Factors
  • Materials
  • Neoplasms
  • New Jersey
  • Phosphodiesterases
  • Programmed Cell Death
  • Proteins
  • Standards
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Oncology (Cancer Research).