Amphyphysin Autoimmunity in Breast Cancer and Stiff-Man Syndrome
Abstract
Stiff-man syndrome (SMS) is a rare neurological disease characterized by rigidity of the body musculature with superimposed painful spasms. Most patients with this disease exhibit autoimmunity to GABA-ergic neurons. It has been found in Prof. De Camilli's laboratory that, to date, all patients diagnosed with breast cancer and SMS, have autoantibodies against a novel synaptic-associated protein, amphiphysin. This research project is to further define the role of anti-amphiphysin antibodies in the development and/or detection of breast cancer and to further understand the function of this protein and how the autoimmunity may arise.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1997
- Accession Number
- ADA335816
Entities
People
- Carol David
Organizations
- Yale University