Wnt-5a and Wnt-4 Regulates Cell Growth in CS7MG Mammary Epithelial Cells

Abstract

The implications for determining whether wnt-5a and wnt-4 act as mediators of normal cell growth are relevant to the detection, diagnosis, and treatment of breast cancer. The intent of this proposal has been to develop new mammary epithelial cell lines which stably express antisense wnt-5a or wnt-4 in order to determine whether the loss of endogenous gene expression of either is important for cell transformation to occur. It was found that disruption of wnt-5a leads to cell transformation and ectopic wnt-5a gene expression in transformed cells reverts cells to a more differentiated phenotype.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1997
Accession Number
ADA335915

Entities

People

  • Daniel J. Olson

Organizations

  • Penn State Milton S. Hershey Medical Center

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cancer
  • Carcinoma
  • Cell Line
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Chromosomes
  • Dna Sequence Analysis
  • Epithelial Cells
  • Gene Expression
  • Genetics
  • Medical Personnel
  • Neoplasms

Readers

  • Oncology (Cancer Research).