A Cohort Study of the Relationship Between c-erbB-2 and Cyclin D1 Overexpression, p53 Mutation and/or Protein Accumulation, and Risk of Progression from Benign Breast Disease to Breast Cancer; and Creation of a Bank of Benign Breast Tissue.
Abstract
Previously, we determined whether c-erbB-2 overexpression and/or p53 protein accumulation with or without gene mutation are molecular markers of increased breast cancer risk. That investigation, which involved 552 subjects, was conducted as a case-control study nested within a cohort of 5,059 women with benign breast disease (BBD) who participated in the National Breast Screening Study (NBSS). The cohort consists of women with histologically-confirmed diagnoses of BBD for whom paraffin blocks are accessible, for whom extensive risk factor data are available, and for whom follow-up status with respect to breast cancer has been determined. Cases are women with benign breast disease who subsequently developed breast cancer. In this study, we propose to: (1) collect paraffin-embedded benign breast material from the remaining 4,507 (that is 5,059-552) cohort members. (2) enlarge our ongoing case-control study' with an additional 38 cases (and their controls) which we anticipate will be identified as a result of a linkage of the NBSS database to the National Cancer Incidence Reporting System. (3) examine whether cyclin D1 overexpression determined immunohistochemically is a molecular marker of risk of progression from BBD to breast cancer. To date, we have updated the data base, completed the cyclin D1 immunostaining of existing blocks, and initiated block collection of the remaining cohort.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1997
- Accession Number
- ADA335979
Entities
People
- Rita A. Kandel
Organizations
- Mount Sinai Hospital, Toronto