The Role of Cyclin D1 Overexpression in Breast Cancer Progression

Abstract

Our previous studies concentrated on the role of cyclin D1 in breast cancer. In recent studies we have found that cyclin E, which also plays a critical role in the G1 to S progression of the cell cycle, is also frequently overexpressed in breast cancer cell lines. We found that ectopic overexpression of cyclin E stimulates the growth of fibroblast cell lines but inhibits the growth of some mammary epithelial cell lines.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1997
Accession Number
ADA335991

Entities

People

  • I. B. Weinstein

Organizations

  • Columbia University

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Computer Programs
  • Culture Techniques
  • E Band
  • Epithelial Cells
  • Genetics
  • Inhibition
  • Inhibitors
  • Medical Personnel
  • Neoplasms
  • Proteins

Readers

  • Molecular Biology and Genetics