Mapping Mammary Carcinoma Suppressor Genes in the Laboratory Rat

Abstract

Inbred strains of rats differ in their susceptibility to both spontaneous and chemically-induced mammary carcinogenesis. We have been using genetic breeding strategies between resistant and susceptible rat strains, followed by linkage analysis to identify the mammary carcinoma susceptibility (Mcs) gene(s) responsible for the mammary carcinoma resistance trait in the inbred Copenhagen (Cop) rat. Simple sequence repeat (SSR) markers from the literature as well as from our chromosome-specific libraries were used to map the Cop rat genome and fine-map the regions involved in the resistance phenotype. So far we have found 4 loci (3 resistance and 1 enhancer) that show linkage with the mammary carcinoma resistance phenotype. The locus on chromosome 2 (termed Mcs1) is believed to contain the major tumor resistance gene, while other loci such as Mcs2 on chromosome 7, Mcs3 on chromosome 1, and Mcs4 on chromosome 8, represent relatively weaker genes.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1997
Accession Number
ADA335993

Entities

People

  • Hong Lan
  • Michael Gould

Organizations

  • University of Wisconsin–Madison

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cancer
  • Chromosomes
  • Computer Programs
  • Data Analysis
  • Genes
  • Genetic Mapping
  • Genetic Phenomena
  • Genetic Structures
  • Genetics
  • Genome
  • Materials
  • Medical Personnel
  • Molecular Dynamics
  • Neoplasms
  • Phenotypes
  • Sequences

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology