Mechanisms of Breast Cancer-Induced Osteolysis.
Abstract
We have demonstrated expression level of the integrin alphavbeta3 correlates with organ-specific targeting of human breast tumor cells, such that low integrin expressing cells preferentially home to bone, while high alphavbeta3 expressing cells preferentially target to lungs. In addition, we have shown that the MDA-231 cells express the osteoclastogenic cytokine IL-6, and directly or indirectly promote expression of a second osteoclast promoting cytokine, IL-1 by the host. Expression of these cytokines likely contributes to the tumor induced osteolysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1997
- Accession Number
- ADA336527
Entities
People
- Steven L. Teitelbaum