Molecular Epidemiology of Breast Cancer: Establishment of an at Risk Cohort and Methods to Improve the Collection and Use of Risk Factor Data
Abstract
The aim of the research program we are developing is to define molecular markers and their interaction with other risk factors as risk indicators for development of breast cancer among women with benign breast disease (BBD). Our specific aims are: (1) Estimate the incidence and time span of breast cancer development in a large cohort of African American and Caucasian women with biopsy-proven BBD; (2) Collect and archive in a specimen bank samples of benign breast disease lesions and breast cancer from women in this cohort; and (3) Develop and test a questionnaire for collecting breast cancer risk factor information that will: (a) allow the construction of an exposure index for lifetime exposure to sex hormones; and (b) designed to be sensitive to the perceptions of African American as well as Caucasian women. We are constructing a cohort of 5353 women with BBD between 1981 to 1991, who will be followed from 5 to 15 years and yield 248 women who will have developed invasive breast cancer. This work is building the foundation, in terms of a cohort, a specimen bank, a survey instrument, and a summary information index, for the conduct of molecular epidemiologic studies of breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1997
- Accession Number
- ADA336806
Entities
People
- Christine C. Johnson
Organizations
- Henry Ford Health