A Miniswine Model of Heatstroke.

Abstract

We developed a miniswine model of passive heatstroke, in part, to explain the variable hyper-, normo- and hypokalemia seen in heatstroke victims. After a baseline period (Tamb=26-270C), anesthetized and instrumented miniswine (n=13, mass=44.6 kg) were ramped t9 41-430C, 60% RH; 13 controls were treated identically, but Tre was maintained at 3800. Tre of the experimental miniswine rose nearly linearly to 454600 until death (approx. 4h). The response patterns of mean arterial pressure, heart rate, plasma K+, LPS, Ca++, inorganic phosphate, lactate and a variety of other clinical chemical and physiological variables were determined. An explanation for the variability of plasma k+ in heatstroke victims was proposed. This model may be useful in characterizing the multisystemic pathology of severe heat injury and be useful for assessing innovative therapeutic regimens.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1997
Accession Number
ADA337448

Entities

People

  • Brian Gentile
  • Michael Koratich
  • Natalie Leva
  • Roger Hubbard
  • Stephen L. Gaffin

Organizations

  • United States Army Research Institute of Environmental Medicine

Tags

DTIC Thesaurus Topics

  • Acid-Base Imbalance
  • Anesthesia
  • Biochemistry
  • Blood
  • Cardiac Arrhythmias
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Heart
  • Heat Stroke
  • Hemorrhagic Shock
  • Laboratory Animals
  • Metabolic Diseases
  • Metabolism
  • New York

Fields of Study

  • Medicine

Readers

  • Allergy and Immunology.
  • Cardiovascular Physiology
  • Computational Modeling and Simulation