The Role of Oxidative Stress in Apoptosis of Breast Cancer Cells

Abstract

In response to specific stimuli, normal cells undergo a process of cell suicide called apoptosis. This project is testing the hypothesis that oxidative stress plays a critical role in the mechanism of apoptosis induced by treatment of human breast cancer cells with tumor necrosis factor-alpha (TNF). TNF treatment of MCF-7 cells was found to increase the expression and activity of manganese superoxide dismutase.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADA337481

Entities

People

  • Margaret M. Briehl

Organizations

  • University of Arizona

Tags

DTIC Thesaurus Topics

  • Aldehydes
  • Antioxidants
  • Apoptosis
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Techniques
  • Diseases And Disorders
  • Free Radicals
  • Neoplasms
  • Oxidative Stress
  • Programmed Cell Death
  • Proteins
  • Transcription Factors
  • Tumor Cell Line

Readers

  • Immunology and Pathology
  • Molecular Biology and Genetics