Virus Detection: Limits and Strategies.
Abstract
The rapid detection of virus particles is a vexing issue to the military and public health communities. The need for a rapid and trustworthy virus detector remains an urgent and continuing requirement for commanders requiring an assurance that they have early warning from these threats. This short report presents a historical summary, with references, of methods used to extract, purify, and concentrate viruses. Working with viruses is not an easy job. The requirement for detection was identified nearly 60 years ago and just now is seeing an approach with the evolution of the Integrated Virus Detector System (IVDS) device to undertake this exacting and difficult task. This work expounds a new methodology - IVDS. The IVDS utilizes a physical process to detect viruses. This is a departure from the traditional approaches that historically have utilized obscure chemical reactions, complicated reagents and other exacting and difficult procedures for detection. The IVDS is based in four physical stages which are collection, separation, purification, and detection. Development and risks are discussed. An IVDS development schedule and costs are given that could lead to an advance prototype in two years. The IVDS system promises a very sensitive, broad spectrum "generic" virus detector free from reagent based reactions, simple to operate, and providing a capability for continuous monitoring and recording of virus levels in the outdoor bioaerosol.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1997
- Accession Number
- ADA337490
Entities
People
- Charles H. Wick
- D. B. Anderson
- Homer R. Yeh
- Hugh R. Carlon
Organizations
- Edgewood Chemical Biological Center