Regulation of Epidermal Growth Factor Receptor Expression by PML in Human Breast Cancer

Abstract

We have determined that PML is a novel growth suppressor that was found to be from chromosome 15 and fused with the retinoic acid receptor-a gene on chromosome 17 (t(15; 17) in acute promyelogenous leukemia (APL). PML is a member of the newly identified growing family of RING finger domain proteins that includes the breast cancer susceptibility gene BRCA1, ret, and T18, whose functions ranged from transactivation of viral genes to DNA repair and extinction of homeotic genes. Expression of PML has been shown to be altered in breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1997
Accession Number
ADA337492

Entities

People

  • Khew-voon Chin

Tags

DTIC Thesaurus Topics

  • Acids
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Growth Factors
  • Leukemia
  • Materials
  • Neoplasms
  • New Jersey
  • Proteins
  • Regulations
  • Retinoic Acids
  • Suppressors
  • Transcription Factors

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology