Role of CD44 and Variants in Membrane-Cytoskeleton Interactions, Adhesion, Metastasis and Human Breast Cancers

Abstract

Previously, we have reported that the expression of CD44v3,8-10 is closely correlated with the metastatic behavior of human breast carcinomas. In this study we have chosen a new breast cancer metastasis model system, Met-I cells (derived from a high metastatic potential tumor in transgenic mice expressing polyomavirus middle T oncogene), to further analyze the functional property of this CD44 variant isoform. We used a variety of techniques (e.g. RT-PCR, Southern blot, immunoprecipitation and immuno-blot techniques).

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1997
Accession Number
ADA337552

Entities

People

  • Lilly Bourguignon

Organizations

  • University of Miami

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Blood
  • Breast Cancer
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Confocal Laser Scanning Microscopy
  • Confocal Microscopy
  • Culture Media
  • Molecules
  • Neoplasms
  • Polymeric Films
  • Polyomaviridae
  • Polysaccharides
  • Proteins

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular Biology and Genetics