Development of a Novel Intravenous Membrane Oxygenator.
Abstract
The Intravenous Membrane Oxygenator (IMO) at the University of Pittsburgh is intended to provide temporary and portable respiratory support to military and civilian personnel whose lungs are acutely damaged and impaired. The current IMO device consists of several hundred hollow fiber membranes (H:FMs) manifolded to gas supply lines for O2 delivery, CO2 removal, and helium supply to a balloon integer located within the fiber bundle. Rapid pulsation of the balloon generates additional convective flow of blood across the HFMs and enhances the rate of O2 delivery and CO2 removal This report describes key progress in the following areas: 1) hollow fiber membrane evaluation; 2) IMO prototype design development; 3) in-vitro gas exchange performance and characterization of the IMO; and 4) acute and chronic animal studies. The IMO prototypes developed under this contract exchanged O2 and CO2 at rates equal to or exceeding our design target for gas transfer per fiber surface area. This target is based on attaining 50% of the normal baseline metabolic requirements for O2 supply and CO2 removal with an IMO device of 0.4 to 0.5 m2 fiber surface area. The next phase of IMO development has already begun and involves scaling-up to full-size IMO devices intended for human implantation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1997
- Accession Number
- ADA337586
Entities
People
- Laura Lund
- Mariah Hout
- Shelly Heinrich
- Todd Hewitt
- William Federspiel
Organizations
- University of Pittsburgh