Breast Cancer in Ataxia Telangiectasia Carriers.
Abstract
Individuals that carry a single mutated copy of the ATM gene appear clinically normal but may be at increased risk for breast cancer and for normal tissue damage from radiotherapy. We have developed a direct sequencing assay that can identify mutations and polymorphisms in the translated region of the ATM message. This assay is being used in a pilot study of the incidence of ATM mutations and polymorphisms in cancer patients, particularly breast cancer patients. If successful, this pilot study will be expanded to a full scale epidemiological study of the role of ATM mutations and polymorphisms in breast cancer susceptibility and normal tissue damage from radiotherapy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1997
- Accession Number
- ADA337820
Entities
People
- Michael M. Weil
Organizations
- University of Texas at Austin