Genetic Immunization for Lentiviral Immunodeficiency Virus Infection and Disease

Abstract

Work proceeded well during the past year. Our experiment to optimize DNA vaccination in primates has been completed and almost all samples are analyzed. We found that optimal DNA vaccination conditions in Macaques are quite different from those that most workers are using and this could account for the weak and transient responses and lack of protection observed to date. We have also completed the design of the challenge experiment and have been vaccinating animals with SIVmac env containing plasmids. We collected samples at monthly intervals and now are in the 4th month post-vaccination. Animals will be reinjected in December and challenged with SIVmac 251 February, 1998.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1997
Accession Number
ADA338248

Entities

People

  • Murray B. Gardner

Organizations

  • University of California

Tags

DTIC Thesaurus Topics

  • Animals
  • Blood
  • Cells
  • Cytokines
  • Data Analysis
  • Immunity
  • Immunization
  • Immunochemistry
  • Immunomodulation
  • Intramuscular Injections
  • Lymphocytes
  • Materials
  • Nucleic Acids
  • Proteins
  • Vaccination
  • Vaccines
  • Viruses

Readers

  • Immunology
  • Molecular Genetics
  • Technical Research and Report Writing.

Technology Areas

  • Biotechnology