Estrogen Effects on Breast Tumor Growth in Estrogen Receptor-Minus Mice
Abstract
Although nearly half of human breast cancers at diagnosis are estrogen-responsive and respond to antiestrogen therapy at least for a time, more than half are estrogen receptor negative (ER-) and are predicted to be estrogen- nonresponsive tumors. However, some tumors which are ER-appear to respond to antiestrogen therapy in patients, which is beneficial because antihormonal therapy is less toxic than the alternative chemotherapy. The SCID mouse model has been recently used to study the hormonal dependence of growth of human breast cancer cells as tumors. Recent work has identified a potential model system where ER- breast cancer cells are estrogen- independent in cell culture, and yet intriguingly show estrogen-stimulated growth as tumors in SCID mice.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1997
- Accession Number
- ADA338761
Entities
People
- Dennis Lubahan
Organizations
- University of Missouri