Anti-Breast Cancer Effects of Vitamin D3 Analogs Either Alone or in Combination with Other Agents.

Abstract

,We have studied the effect of vitamin D analogs on growth of various breast cancer cell lines in vitro as well as in vivo and have identified the 19-nor-hexafluoride analogs as being particularly potent in their activity. Furthermore, we have found that vitamin D3 analogs can synergize with Taxol in inhibiting breast cancer. We have recently found that trogliterazone, a synthetic ligand of the peroxisome proliferator/activated receptor y (PPARy) can inhibit the growth of breast cancer cells and this PPARy ligand with All-trans-retinoic acid can induce apoptosis of breast cancer cells. Furthermore, we have looked for genetic alterations of breast cancer including identification of alterations of the cyclin-dependent-kinase inhibitor genes including p27KIPl and the p16' NK4A genes.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1997
Accession Number
ADA338767

Entities

People

  • Phillip H. Koeffler

Organizations

  • Cedars-Sinai Medical Center

Tags

DTIC Thesaurus Topics

  • Acids
  • Antineoplastic Agents
  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Reactions
  • Chromosomes
  • Inhibitors
  • Molecular Biology
  • Neoplasms
  • Polymerase Chain Reaction
  • Retinoic Acids
  • Tumor Cell Line
  • Vitamin D

Fields of Study

  • Chemistry

Readers

  • Oncology (Cancer Research).
  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology