The RIZ Gene in Human Breast Cancer

Abstract

The RIZ gene was isolated based on binding to the retinoblastoma tumor suppressor protein. RIZ gene normally produces two protein products, RIZ1 and RIZ2, that differ in length by the presence or absence of a conserved protein motif, the PR domain, found in a subfamily of Kruppel-like zinc finger genes. RIZ2 lacks the PR domain. RIZ gene maps to human chromosome band 1p36, a region that is commonly deleted or altered in a variety of human cancers including those of breast, neurocrest, colon, and liver tissues. RIZ1 and RIZ2 are widely expressed in normal tissues. However, RIZ1 was undetectable in 4 of 5 breast carcinoma specimens and in 4 of 10 breast cancer cell lines.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADA338850

Entities

People

  • Shi Huang

Organizations

  • Sanford Burnham Prebys Medical Discovery Institute

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Carcinoma
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chromosomes
  • Epithelial Cells
  • Gene Expression
  • Genes
  • Genetics
  • Neoplasms
  • Proteins
  • Retinal Diseases
  • Suppressors
  • Tumor Cell Line

Readers

  • Molecular Biology and Genetics
  • Molecular Genetics